

See below for a list of existing research on the nutrients in mushrooms and how they may help in disease prevention. This research is just the beginning of what is sure to be an exciting journey into a fuller understanding of mushrooms and your health.
Visit www.mushroomsandhealth.com for the in-depth, evidence-based report, “Mushrooms and Health.”
Nutrient Composition
- U.S. Department of Agriculture, Agricultural Research Service, USDA Nutrient Data Laboratory. 2009. USDA National Nutrient Database for Standard Reference, Release 22. USDA Nutrient Data Laboratory website: http://www.ars.usda.gov/nutrientdata.
- Koyyalamudi, S.R., Jeong, S.C., Cho, K.Y., & Pang, G. (2009). Vitamin B12 is the active corrinoid produced in cultivated white button mushrooms (Agaricus bisporus). Journal of Agricultural and Food Chemistry, 57, 6327-6333.
- Rop, O., Mlcek, J., & Jurikova, T. (2009). Beta-glucans in higher fungi and their health effects. Nutrition Reviews, 67, 624-631.
- Falandysz, J. (2008). Selenium in edible mushrooms. Journal of Environmental Science and Health, 26, 256-299.
- Feeney, M. J. (2006, September/October). Mushrooms–intake, composition, and research. Nutrition Today, 41, 219-26.
- Dikeman, C. L., et al. (2005). Effects of stage of maturity and cooking on the chemical composition of select mushroom varieties. Journal of Agricultural and Food Chemistry, 1130-8.
- Mattila, P., et al. (2002). Basic composition and amino acid contents of mushrooms cultivated in Finland. Journal of Agricultural and Food Chemistry, 50, 6419-22.
- Mattila, P., et al. (2001). Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. Journal of Agricultural and Food Chemistry, 49, 2343-8.
Cancer
- Shen, J., et al. (2009). Effect of the culture extract of Lentinus edodes mycelia on splenic sympathetic activity and cancer cell proliferation. Autonomic Neuroscience: Basic & Clinical, 145, 50-4.
- Zhang, M., Huang, J., Xie, X. & Holman, C.D. (2009). Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. International Journal of Cancer, 124, 1404-8.
- Martin, K.R., & Brophy, S. (2009) Dietary mushrooms reduce mitogenesis and induce apoptosis and cytotoxicity in MCF-7 human breast cancer cells. Experimental Biology, New Orleans, LA.
- Hong, S.A., Kim, K., Nam, S.J., Kong, G., & Kim, M.K. (2008). A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean women. International Journal of Cancer, 122, 919-23.
- Adams, L.S., Phung, S., Wu, X., Ki, L., & Chen, S. (2008). White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. Nutrition and Cancer, 60, 744-56.
- Jedinak, A., & Sliva, D. (2008). Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. International Journal of Oncology, 33, 1307-13.
- City of Hope Research on Breast and Prostate Cancer: Researchers study mushrooms’ cancer-fighting potential
- Chen, S., et al. (2006). Anti-aromatase activity of phytochemicals in white button mushrooms. Cancer Research, 66, 12026-34.
- Chen, S., et al. (2005). Chemopreventive properties of mushrooms against breast cancer and prostate cancer. International Journal of Medicinal Mushrooms, 7, 342-3.
- Stanley, G., et al. (2005). Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-ß1 from prostate cancer cells. Biochemical and Biophysical Research Communications, 330, 46-52.
- Hara, M., et al. (2003). Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Nutrition and Cancer, 46, 138-47.
- Sliva, D., et al. (2003). Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells. The Journal of Alternative and Complementary Medicine, 9, 491-7.
- Smith, J. E., et al. (2002). Medicinal mushrooms: Their therapeutic properties and current medical usage with special emphasis on cancer treatments. Cancer Research UK.
- Kodama, N., et al. (2002). Can maitake MD-fraction aid cancer patients? Alternative Medicine Review, 7, 236-9.
- Wasser, S. P. (2002). Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology, 60, 258-74.
- Grube, B. J., et al. (2001). White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. The Journal of Nutrition, 131, 3288-93.
- Kidd, P.M., et al. (2000). The use of mushroom glucans and proteoglycans in cancer treatment. Alternative Medicine Review, 5, 4-27.
Antioxidants and Immunity/Inflammation
Antioxidants:
- Savoie, J.M., Minvielle, N., & Largeteau, M.L. (2008). Radical-scavenging properties of extracts from the white button mushroom, Agaricus bisporus. Journal of the Science of Food and Agriculture, 88, 970-975.
- Elmastas, M., et al. (2007). Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms. Journal of Food Composition and Analysis, 20, 337-45.
- Dubost, N. J., et al. (2007). Quantification of polyphenols and ergothioneine in cultivated mushrooms and correlation to total antioxidant capacity. Food Chemistry, 105, 727-735.
- Dubost, N. J., et al. (2006). Identification and quantification of ergothioneine in cultivated mushrooms by liquid chromatography-mass spectroscopy. International Journal of Medicinal Mushrooms, 8, 215-22.
- Lakshmi, B., et al. (2004). Evaluation of antioxidant activity of selected Indian mushrooms. Pharmaceutical Biology, 42, 179-85.
- Pellegrini, N., et al. (2003). Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays.The Journal of Nutrition, 133, 2812-9.
- Miller, H. E., et al. (2000). Antioxidant content of whole grain breakfast cereals, fruits and vegetables. Journal of the American College of Nutrition, 19, 312S-95S.
Immunity/Inflammation:
- Sanhong, Y., Weaver, V., Martin, K., & Cantorna, M.T. (2009) The effects of whole mushrooms during inflammation. BMC Immunology, 10.
- Traore, D., Peterson, S., Alexander, H., Sharp, D., Clarke, S., Lucas, E., Smith, B.J., & Kuvibidila, S. (2009). The effects of Portabella mushrooms on bone mineral density and body composition in mice without and with collagen induced arthritis. Experimental Biology, New Orleans, LA.
- Kuvibidila, S., Alexander, H., Lim, Y.F., Christopher, L., Lucas, E., Clarke, S.L., & Smith, B.J. (2009). White button, Shiitake, and Portabella mushrooms modulate the development of collagen-induced arthritis in mice. Experimental Biology, New Orleans, LA.
- Ren Z, Guo Z, Meydani SN, Wu D. White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice The Journal of Nutrition, 138, 544-550.
- Wu, D, Pae M, Ren Z, Guo Z, et al. Dietary Supplementation with White Button Mushroom Enhances Natural Killer Cell Activity Journal of Nutrition, 137, 1472-1477.
Weight Management/Satiety
- Cheskin, L.J., et al. (2008). Lack of energy compensation over 4 days when white button mushrooms are substituted for beef. Appetite, 51, 50-57.
- Kloss, R., et al. (2006). Body weight and composition changes after consumption of two different very low carbohydrate diets versus a lower fat diet. Experimental Biology, San Francisco, CA. Abstract #267.8.
Umami and Sodium
- Bellisle, F. (2008). Experimental studies of food choices and palatability responses in European subjects exposed to the Umami taste. Asia Pacific Journal of Clinical Nutrition, 17, 358.
- Manabe, M. (2008) Saltiness enhancement by the characteristic flavor of dried bonito stock. Journal of Food Science, 73, S321-5.
- McCabe, C., & Rolls, E.T. (2007). Umami: a delicious flavor formed by convergence of taste and olfactory pathways in the human brain. European Journal of Neuroscience, 25, 1855-64.
- Rotzoll, N., Dunkel, A., & Hofmann, T. (2006) Quantitative studies, taste reconstitution, and omission experiments on the key taste compounds in morel mushrooms (Morchella deliciosa). Journal of Agricultural and Food Chemistry, 54, 2705-11.
- Prescott, J. (2004). Effects of added glutamate on liking for novel food flavors. Appetite, 42, 143-50.
- Ball, P., Woodward, D., Beart, T., Shoobridge, A., & Ferrier, M. (2002). Calcium diglutamate improves taste characteristics of lower-salt soup. European Journal of Clinical Nutrition, 56, 519-23.
- Yamaguchi, S., & Ninomiya, K. (2000). Umami and food palatability. Journal of Nutrition, 130, 921S-6S.
- Halpern, B.P. (2000). Glutamate and the flavor of foods. Journal of Nutrition, 130, 910S-4S.
Vitamin D
- Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin D. http://ods.od.nih.gov/factsheets/vitamind.asp#h3. Accessed: March 10, 2010
- U.S. Department of Agriculture, Agricultural Research Service, USDA Nutrient Data Laboratory. 2009. USDA National Nutrient Database for Standard Reference, Release 22. USDA Nutrient Data Laboratory website: http://www.ars.usda.gov/nutrientdata.
- Koyyalamudi, S.R., Jeona, S.C., Song, C.H., & Pang, G. (2009). Vitamin D2 formation and bioavailability from Agaricus bisporus button mushrooms treated with ultraviolet irradiation. Journal of Agricultural and Food Chemistry, 57, 3351-5.
- Holick, M.F., et al. (2008). Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. Journal of Clinical Endocrinology & Metabolism, 93, 677-681.
- Ozzard, A., & Hear, G. (2008). Vitamin D deficiency treated by consuming UVB-irradiated mushrooms. British Journal of General Practice, 58, 644-645.
- Roberts, J.S., Teichert, A., & McHugh, T.H. (2008). Vitamin D2 formation from post-harvest UV-B treatment of mushrooms (Agaricus bisporus) and retention during storage. Journal of Agricultural and Food Chemistry, 25, 4541-4.
- Ko, J.A., Lee, B.H., Lee, J.S., & Park, H.J. (2008). Effect of UV-B exposure on the concentration of vitamin D2 in sliced shiitake mushroom (Lentinus edodes) and white button mushroom (Agaricus bisporus). Journal of Agricultural and Food Chemistry, 56, 3671-4.
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Holick, MF. Vitamin D Deficiency. N Engl J Med 2007; 357:266-81.
- Feeney, M. J. (2006). Mushrooms–intake, composition, and research. Nutrition Today, 41, 219-26.
- Dikeman, C.L., Bauer, L.L., Flickinger, E.A., & Fahey, Jr., G.C. (2005). Effects of stage of maturity and cooking on the chemical composition of select mushroom varieties. Journal of Agricultural and Food Chemistry, 1130-8.
- Mattila, P., Salo-Vaananen, P., Konko, K., Aro, H., & Jalava, T. (2002). Basic composition and amino acid contents of mushrooms cultivated in Finland. Journal of Agricultural and Food Chemistry, 50, 6419-22.
- Mattila, P., et al. (2001). Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. Journal of Agricultural and Food Chemistry, 49, 2343-8.
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Palmieri, C., MacGregor, T., Girgis, S., & Vigushin, D. (2006). Serum 25 hydroxyvitamin D levels in early and advanced breast cancer. Journal of Clinical Pathology, 59, 1334-6.
Other Benefits
- Jeong, S.C., et al. (2010). White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutrition Research, 30, 49-56.
- Bradley, P., et al. (2006). Blood lipid responses to consumption of two different very low carbohydrate diets versus a lower fat diet. Experimental Biology, San Francisco, CA. Abstract #109.4.
- Petrisko, Y., et al. (2006). Postprandial serum triglyceride responses following four weeks of consuming two different very low carbohydrate diets versus a lower fat diet. Experimental Biology, San Francisco, CA. Abstract #109.5
- Chang, S.T., & Buswell, J.S. (2003). Medicinal mushrooms – a prominent source of nutriceuticals for the 21st Century. Current Topics in Nutraceutical Research, 1, 257-80.
- Mattila, P., Suonpaa, M., & Piironen, V. (2000). Functional properties of edible mushrooms. Nutrition, 16, 694-6.
- Chang, R. (1996). Functional properties of edible mushrooms. Nutrition Reviews, 54, S91-S93.


